One year ago, a supermoon event triggered a global outbreak, transforming anyone exposed to moonlight into bloodthirsty werewolves for just one night. Now, as the next supermoon rises, former marine and Global Rapid Response Team Leader Wesley Marshall (Frank Grillo) teams up with scientists Dr. Aranda (Lou Diamond Phillips) and Dr. Amy Chen (Katrina Law) to find a cure before humanity is lost, but as chaos and carnage unfold, Marshall must fight off killer beasts and risk everything to protect his family.