A retired security guard (Robert De Niro), deeply conservative and set in his ways, falls victim to a debilitating stroke. His doctors prescribe an extensive program of physical therapy once he's released from the hospital, including singing lessons to help him regain his full powers of speech. As it turns out, there's a vocal instructor living next door to the guard, so he signs up only to discover that his new teacher is a flamboyant drag queen awaiting a sex-change operation (Philip Seymour Hoffman).